Structure of PDB 2r3y Chain A Binding Site BS01

Receptor Information
>2r3y Chain A (length=280) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MTPASYNLAVRRAAPAVVNVYNRGLNTNSHNQLEIRTLGSGVIMDQRGYI
ITNKHVINDADQIIVALQDGRVFEALLVGSDSLTDLAVLKINATGGLPTI
PINARRVPHIGDVVLAIGNPYNLGQTITQGIISATGRIGLNPTGRQNFLQ
TDASINHGNSGGALVNSLGELMGINTLSFDKSNDGETPEGIGFAIPFQLA
TKIMDKLIRDGRVIRGYIGIGGIVVNEVSPDGPAANAGIQVNDLIISVDN
KPATMDQVAEIRPGSVIPVVVLQVTIQEYP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2r3y Regulation of the sigmaE stress response by DegS: how the PDZ domain keeps the protease inactive in the resting state and allows integration of different OMP-derived stress signals upon folding stress.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		L124 G185 R186 Y258 I259 I261 G263 M319 V322
Binding residue
(residue number reindexed from 1)		L83 G144 R145 Y217 I218 I220 G222 M255 V258
Enzymatic activity
Enzyme Commision number 3.4.21.107: peptidase Do.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2r3y, PDBe:2r3y, PDBj:2r3y
PDBsum2r3y
PubMed17938245
UniProtP0AEE3|DEGS_ECOLI Serine endoprotease DegS (Gene Name=degS)

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