Structure of PDB 2qpt Chain A Binding Site BS01

Receptor Information
>2qpt Chain A (length=476) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RTVTSSLKELYRTKLLPLEEHYRFGSFHSPALEDADFDGKPMVLVAGQYS
TGKTSFIQYLLEQEVPGSRVGPEPTTDCFVAVMHGETEGTVPGNTFLNRF
MCAQLPNQVLESISIIDTPGILSRGYDFPAVLRWFAERVDLIILLFDAHK
LEISDEFSEAIGALRGHEDKIRVVLNKADMVETQQLMRVYGALMWALGKV
VGTPEVLRVYIGSFWSQPLLVPDNRRLFELEEQDLFRDIQGLPRHAALRK
LNDLVKRARLVRVHAYIISYLKKEMPTVFGKENKKKQLILKLPVIFAKIQ
LEHHISPGDFPDCQKMQELLMAHDFTKFHSLKPKLLEALDDMLAQDIAKL
MPLLRQEELESVEAGVAGGAFEGTRMGPFVEWVVTKDKSKYDEIFYNLAP
ADGKLSGSKAKTWMVGTKLPNSVLGRIWKLSDVDRDGMLDDEEFALASHL
IEAKLEGHGLPTNLPRRLVPPSKRRQ
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain2qpt Chain A Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB2qpt Architectural and mechanistic insights into an EHD ATPase involved in membrane remodelling.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		D494 D496 D498 M500 E505
Binding residue
(residue number reindexed from 1)		D432 D434 D436 M438 E443
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0019904 protein domain specific binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006897 endocytosis
GO:0030866 cortical actin cytoskeleton organization
GO:0032456 endocytic recycling
GO:0072659 protein localization to plasma membrane
GO:0097320 plasma membrane tubulation
GO:1901741 positive regulation of myoblast fusion
GO:2001137 positive regulation of endocytic recycling
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0010008 endosome membrane
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
GO:0045171 intercellular bridge
GO:0048471 perinuclear region of cytoplasm
GO:0055038 recycling endosome membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2qpt, PDBe:2qpt, PDBj:2qpt
PDBsum2qpt
PubMed17914359
UniProtQ8BH64|EHD2_MOUSE EH domain-containing protein 2 (Gene Name=Ehd2)

[Back to BioLiP]