Structure of PDB 2qki Chain A Binding Site BS01

Receptor Information
>2qki Chain A (length=631) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PMYSIITPNILRLESEETMVLEAHDAQGDVPVTVTVHDFPGKKLVLSSEK
TVLTPATNHMGNVTFTIPANRGRNKFVTVQATFGTQVVEKVVLVSLQSGY
LFIQTDKTIYTPGSTVLYRIFTVNHKLLPVGRTVMVNIENPEGIPVKQDS
LSSQNQLGVLPLSWDIPELVNMGQWKIRAYYENSPQQVFSTEFEVKEYVL
PSFEVIVEPTEKFYYIYNEKGLEVTITARFLYGKKVEGTAFVIFGIQDGE
QRISLPESLKRIPIEDGSGEVVLSRKVLLDGVQRAEDLVGKSLYVSATVI
LHSGSDMVQAERSGIPIVTSPYQIHFTKTPKYFKPGMPFDLMVFVTNPDG
SPAYRVPVAVQGEDTVQSLTQGDGVAKLSINTHPSQKPLSITVRTKKQEL
SEAEQATRTMQALPYSTVGNSNNYLHLSVLRTELRPGETLNVNFLLRMDR
AHEAKIRYYTYLIMNKGRLLKAGRQVREPGQDLVVLPLSITTDFIPSFRL
VAYYTLIGASGQREVVADSVWVDVKDSCVGSLVVKSGQSQPVPGQQMTLK
IEGDHGARVVLVAVDKGVFVLNKKNKLTQSKIWDVVEKADIGCTPGSGKD
YAGVFSDAGLTFTSSSGQQTAQRAELQCPQP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2qki Structure of compstatin in complex with complement component C3c reveals a new mechanism of complement inhibition.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		G345 P347 N390 T391 L454 R456 M457 R459 E462 R486 G489 D491
Binding residue
(residue number reindexed from 1)		G336 P338 N381 T382 L445 R447 M448 R450 E453 R477 G480 D482
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004866 endopeptidase inhibitor activity

View graph for
Molecular Function
External links
PDB RCSB:2qki, PDBe:2qki, PDBj:2qki
PDBsum2qki
PubMed17684013
UniProtP01024|CO3_HUMAN Complement C3 (Gene Name=C3)

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