Structure of PDB 2qjc Chain A Binding Site BS01

Receptor Information

>2qjc Chain A (length=222) Species: 5691 (Trypanosoma brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

YANVVTLPNVTGRVIIVGDIHGCRAQLEDLLRAVSFKQGSDTLVAVGDLV
NKGPDSFGVVRLLKRLGAYSVLGNHDAKLLKLVKKLSLAPLAQSIPTDVE
TYLSQLPHIIRIPAHNVMVAHAGLHPQRPVDRQYEDEVTTMRNLIEKVTL
TATEETNDGGKPWASMWRGPETVVFGHDARRGLQEQYKPLAIGLDSRCVY
GGRLSAAVFPGGCIISVPGWNG

Ligand information

Ligand ID

InChI

InChI=1S/Mn/q+2

InChIKey

WAEMQWOKJMHJLA-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mn+2]
CACTVS 3.341	[Mn++]

Formula

Name

MANGANESE (II) ION

PDB chain

2qjc Chain A Residue 400 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	2qjc Structural genomics of protein phosphatases.
Resolution	2.05 Å
Binding residue (original residue number in PDB)	D26 H28 D55
Binding residue (residue number reindexed from 1)	D19 H21 D48
Annotation score	1

Enzymatic activity

Enzyme Commision number

3.6.1.41: bis(5'-nucleosyl)-tetraphosphatase (symmetrical).

Gene Ontology

	Molecular Function
GO:0000298	endopolyphosphatase activity
GO:0004722	protein serine/threonine phosphatase activity
GO:0008803	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity
GO:0016787	hydrolase activity
GO:0016791	phosphatase activity
GO:0046872	metal ion binding

	Biological Process
GO:0006470	protein dephosphorylation
GO:0006798	polyphosphate catabolic process

	Cellular Component
GO:0005737	cytoplasm

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Cellular Component

External links

PDB	RCSB:2qjc, PDBe:2qjc, PDBj:2qjc
PDBsum	2qjc
PubMed	18058037
UniProt	Q57U41

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