Structure of PDB 2q8e Chain A Binding Site BS01
Receptor Information
>2q8e Chain A (length=344) Species:
9606
(Homo sapiens) [
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SESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKE
WKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIAN
SDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGR
LRTILDLVEKESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHF
GEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKK
YGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQ
AVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLP
Ligand information
>2q8e Chain F (length=4) [
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GGVK
Receptor-Ligand Complex Structure
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PDB
2q8e
Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase.
Resolution
2.05 Å
Binding residue
(original residue number in PDB)
I168 E169 G170 Y175 Y177 S288 N290 V313 K314
Binding residue
(residue number reindexed from 1)
I166 E167 G168 Y173 Y175 S286 N288 V311 K312
Enzymatic activity
Catalytic site (original residue number in PDB)
G170 Y177 H188 E190 H276 S288
Catalytic site (residue number reindexed from 1)
G168 Y175 H186 E188 H274 S286
Enzyme Commision number
1.14.11.66
: [histone H3]-trimethyl-L-lysine(9) demethylase.
1.14.11.69
: [histone H3]-trimethyl-L-lysine(36) demethylase.
External links
PDB
RCSB:2q8e
,
PDBe:2q8e
,
PDBj:2q8e
PDBsum
2q8e
PubMed
17589523
UniProt
O75164
|KDM4A_HUMAN Lysine-specific demethylase 4A (Gene Name=KDM4A)
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