Structure of PDB 2q8d Chain A Binding Site BS01
Receptor Information
>2q8d Chain A (length=347) Species:
9606
(Homo sapiens) [
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MASESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPP
KEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKI
ANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNI
GRLRTILDLVEKESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYL
HFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLML
KKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYG
KQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPT
Ligand information
>2q8d Chain F (length=4) [
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GGVK
Receptor-Ligand Complex Structure
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PDB
2q8d
Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase.
Resolution
2.29 Å
Binding residue
(original residue number in PDB)
I168 E169 G170 Y175 Y177 S288 D311 V313 K314
Binding residue
(residue number reindexed from 1)
I168 E169 G170 Y175 Y177 S288 D311 V313 K314
Enzymatic activity
Catalytic site (original residue number in PDB)
G170 Y177 H188 E190 H276 S288
Catalytic site (residue number reindexed from 1)
G170 Y177 H188 E190 H276 S288
Enzyme Commision number
1.14.11.66
: [histone H3]-trimethyl-L-lysine(9) demethylase.
1.14.11.69
: [histone H3]-trimethyl-L-lysine(36) demethylase.
External links
PDB
RCSB:2q8d
,
PDBe:2q8d
,
PDBj:2q8d
PDBsum
2q8d
PubMed
17589523
UniProt
O75164
|KDM4A_HUMAN Lysine-specific demethylase 4A (Gene Name=KDM4A)
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