Structure of PDB 2q3c Chain A Binding Site BS01

Receptor Information

>2q3c Chain A (length=300) Species: 1773 (Mycobacterium tuberculosis)

MSIAEDITQLIGRTPLVRLRRVTDGAVADIVAKLEFFNPANSVKDRIGVA
MLQAAEQAGLIKPDTIILEPTSGNTGIALAMVCAARGYRCVLTMPETMSL
ERRMLLRAYGAELILTPGADGMSGAIAKAEELAKTDQRYFVPQQFENPAN
PAIHRVTTAEEVWRDTDGKVDIVVAGVGTGGTITGVAQVIKERKPSARFV
AVEPAASPVLSGGQKGPHPIQGIGAGFVPPVLDQDLVDEIITVGNEDALN
VARRLAREEGLLVGISSGAATVAALQVARRPENAGKLIVVVLPDFGERYL

Ligand information

>2q3c Chain B (length=4) Species: 1773 (Mycobacterium tuberculosis)

DFSI

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2q3c Structural Insights into Catalysis and Inhibition of O-Acetylserine Sulfhydrylase from Mycobacterium tuberculosis: CRYSTAL STRUCTURES OF THE ENZYME {alpha}-AMINOACRYLATE INTERMEDIATE AND AN ENZYME-INHIBITOR COMPLEX.
• Resolution: 2.1 Å
• Binding residue (original residue number in PDB): T71 S72 G73 T75 M122 Q144 K215 G222 A225
• Binding residue (residue number reindexed from 1): T71 S72 G73 T75 M122 Q144 K215 G222 A225

Enzymatic activity

• Catalytic site (original residue number in PDB): K44 S266 P293
• Catalytic site (residue number reindexed from 1): K44 S266 P293
• Enzyme Commision number: 2.5.1.47: cysteine synthase.

Gene Ontology

Molecular Function

• GO:0004124 cysteine synthase activity
• GO:0005515 protein binding
• GO:0016740 transferase activity
• GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
• GO:0030170 pyridoxal phosphate binding
• GO:0080146 L-cysteine desulfhydrase activity

Biological Process

• GO:0006535 cysteine biosynthetic process from serine
• GO:0019344 cysteine biosynthetic process

Cellular Component

• GO:0005576 extracellular region
• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:2q3c, PDBe:2q3c, PDBj:2q3c
• PDBsum: 2q3c
• PubMed: 17567578
• UniProt: P9WP55|CYSK_MYCTU O-acetylserine sulfhydrylase (Gene Name=cysK1)