Structure of PDB 2q0e Chain A Binding Site BS01

Receptor Information

>2q0e Chain A (length=331) Species: 5691 (Trypanosoma brucei)

PSPAVVGRSLVNSFKQFVSKDLHTRHVDATYRLVLDCVAAVDPLMRLYTF
GSTVVYGVHEKGSDVDFVVLNKTDVEDGKGGDAATQVAKGLQADILAKLA
RVIRQKHLSWNVEEVRRTRVPVVRVKGGGAVDFDITAYRRNGVRNSALLR
AYFEQNPPCRWLSMSIKRWSKQTGLNASVIGGSITSYGFNLMVVYYLLQR
NHLQFVPPSTIDVSRVEPLPPHLPLEEPADEGLELGTQVLDFLHFFLHEF
DSDKQVISLNRPGITTKEELDWTKSAEDFARMNGEKVHYQWCIEDPYELN
LNVGRNVTPLKRDFLRRHLEKARDTALLTIV

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 2q0e Chain A Residue 401

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2q0e Dual role of the RNA substrate in selectivity and catalysis by terminal uridylyl transferases.
• Resolution: 2.1 Å
• Binding residue (original residue number in PDB): D66 D68
• Binding residue (residue number reindexed from 1): D64 D66
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.7.7.52: RNA uridylyltransferase.

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0003723 RNA binding
• GO:0016779 nucleotidyltransferase activity
• GO:0046872 metal ion binding
• GO:0050265 RNA uridylyltransferase activity

Biological Process

• GO:0071076 RNA 3' uridylation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005739 mitochondrion
• GO:0020023 kinetoplast

External links

• PDB: RCSB:2q0e, PDBe:2q0e, PDBj:2q0e
• PDBsum: 2q0e
• PubMed: 17785418
• UniProt: Q381M1|TUT4_TRYB2 Terminal uridylyltransferase 4 (Gene Name=TUT4)