Structure of PDB 2pvf Chain A Binding Site BS01

Receptor Information
>2pvf Chain A (length=288) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ELPEDPKWEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPVTVAVKML
KDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK
GNLREYLRARRPPGMEYSYQMTFKDLVSCTYQLARGMEYLASQKCIHRDL
AARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFD
RVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPAN
CTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2pvf A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		D626 R630 L665 P666 W669 V709
Binding residue
(residue number reindexed from 1)		D149 R153 L188 P189 W192 V232
Enzymatic activity
Catalytic site (original residue number in PDB) D626 A628 R630 N631 D644
Catalytic site (residue number reindexed from 1) D149 A151 R153 N154 D167
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2pvf, PDBe:2pvf, PDBj:2pvf
PDBsum2pvf
PubMed17803937
UniProtP21802|FGFR2_HUMAN Fibroblast growth factor receptor 2 (Gene Name=FGFR2)

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