Structure of PDB 2pqx Chain A Binding Site BS01

Receptor Information

>2pqx Chain A (length=245) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

LALQAKQYGDFDRYVLALSWQTGFCQSQHDRNRNERDECRLQTETTNKAD
FLTVHGLWPGLPKSVAARGVDERRWMRFGCATRPIPNLPEARASRMCSSP
ETGLSLETAAKLSEVMPGAGGRSCLERYEYAKHGACFGFDPDAYFGTMVR
LNQEIKESEAGKFLADNYGKTVSRRDFDAAFAKSWGKENVKAVKLTCQGN
PAYLTEIQISIKADAINAPLSANSFLPQPHPGNCGKTFVIDKAGY

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

2pqx Chain A Residue 500 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	2pqx Crystal structure of E. coli ribonuclease 1
Resolution	1.42 Å
Binding residue (original residue number in PDB)	Q26 D241 K242 G244
Binding residue (residue number reindexed from 1)	Q26 D241 K242 G244
Annotation score	4

Enzymatic activity

Enzyme Commision number

4.6.1.21: Enterobacter ribonuclease.

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0004519	endonuclease activity
GO:0008847	Enterobacter ribonuclease activity
GO:0016829	lyase activity
GO:0033897	ribonuclease T2 activity

	Biological Process
GO:0006401	RNA catabolic process

	Cellular Component
GO:0005737	cytoplasm
GO:0030288	outer membrane-bounded periplasmic space
GO:0042597	periplasmic space

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:2pqx, PDBe:2pqx, PDBj:2pqx
PDBsum	2pqx
PubMed
UniProt	P21338\|RNI_ECOLI Ribonuclease I (Gene Name=rna)

[Back to BioLiP]