Structure of PDB 2pom Chain A Binding Site BS01

Receptor Information
>2pom Chain A (length=355) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SWTDDLPLCHLSGVGSASNRSYSADGKGTESHPPEDSWLKFRSENNCFLY
GVFNGYDGNRVTNFVAQRLSAELLLGQLNAEHAEADVRRVLLQAFDVVER
SFLESIDDALAEKASLQSQLPEGVPQHQLPPQYQKILERLKTLEREISGG
AMAVVAVLLNNKLYVANVGTNRALLCKSTVDGLQVTQLNVDHTTENEDEL
FRLSQLGLDAGKIKQVGIICGQESTRRIGDYKVKYGYTDIDLLSAAKSKP
IIAEPEIHGAQPLDGVTGFLVLMSEGLYKALEAAHGPGQANQEIAAMIDT
EFAKQTSLDAVAQAVVDRVKRIHSDTFASGGERARFCPRHEDMTLLVRNF
GYPLG
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain2pom Chain A Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB2pom XIAP Induces NF-kappaB Activation via the BIR1/TAB1 Interaction and BIR1 Dimerization.
Resolution2.27 Å
Binding residue
(original residue number in PDB)		N69 G70
Binding residue
(residue number reindexed from 1)		N54 G55
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004722 protein serine/threonine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2pom, PDBe:2pom, PDBj:2pom
PDBsum2pom
PubMed17560374
UniProtQ15750|TAB1_HUMAN TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (Gene Name=TAB1)

[Back to BioLiP]