Structure of PDB 2pgq Chain A Binding Site BS01

Receptor Information
>2pgq Chain A (length=43) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYID
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2pgq Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2pgq Important role of the cys-191 cys-220 disulfide bond in thrombin function and allostery
Resolution1.8 Å
Binding residue
(original residue number in PDB)		D1A K9
Binding residue
(residue number reindexed from 1)		D17 K26
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2pgq, PDBe:2pgq, PDBj:2pgq
PDBsum2pgq
PubMed17636263
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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