Structure of PDB 2pcu Chain A Binding Site BS01

Receptor Information
>2pcu Chain A (length=305) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NNFNYGAYHSLEAIYHEMDNIAADFPDLARRVKIGHSFENRPMYVLKFST
GKGVRRPAVWLNAGIHSREWISQATAIWTARKIVSDYQRDPAITSILEKM
DIFLLPVANPDGYVYTQTQNRLWRKTRSRNPGSSCIGADPNRNWNASFAG
KGASDNPCSEVYHGPHANSEVEVKSVVDFIQKHGNFKGFIDLHSYSQLLM
YPYGYSVKKAPDAEELDKVARLAAKALASVSGTEYQVGPTCTTVYPASGS
SIDWAYDNGIKFAFTFELRDTGTYGFLLPANQIIPTAEETWLGLKTIMEH
VRDNL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2pcu Caught after the Act: a human A-type metallocarboxypeptidase in a product complex with a cleaved hexapeptide.
Resolution1.6 Å
Binding residue
(original residue number in PDB)		H69 R71 E72 R127 E163 H196 S197 Y198 V247 Y248 E270
Binding residue
(residue number reindexed from 1)		H66 R68 E69 R124 E160 H193 S194 Y195 V244 Y245 E267
Enzymatic activity
Catalytic site (original residue number in PDB) H69 E72 R127 H196 E270
Catalytic site (residue number reindexed from 1) H66 E69 R124 H193 E267
Enzyme Commision number 3.4.17.-
Gene Ontology
Molecular Function
GO:0004181 metallocarboxypeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2pcu, PDBe:2pcu, PDBj:2pcu
PDBsum2pcu
PubMed17506531
UniProtQ9UI42|CBPA4_HUMAN Carboxypeptidase A4 (Gene Name=CPA4)

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