Structure of PDB 2p8e Chain A Binding Site BS01

Receptor Information
>2p8e Chain A (length=278) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FLDKPKTEKHNAHGAGNGLRYGLSSMQGWRVEMEDAHTAVVGIPHGLEDW
SFFAVYDGHAGSRVANYCSTHLLEHITTNEDFRSVENVKNGIRTGFLKID
EYMRNFSDLRDRSGSTAVGVMISPKHIYFINCGDSRAVLYRNGQVCFSTQ
DHKPCNPREKERIQNAGGSVMIQRVNGSLAVSRALGDYDYKCVDGKGPTE
QLVSPEPEVYEILRAEEDEFIILACDGIWDVMSNEELCEYVKSRLEVSDD
LENVCNWVVDTCLHKGSRDNMSIVLVCF
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain2p8e Chain A Residue 306 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2p8e Structural genomics of protein phosphatases.
Resolution1.816 Å
Binding residue
(original residue number in PDB)		D60 C242 D243 D286
Binding residue
(residue number reindexed from 1)		D57 C225 D226 D269
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.3.16: protein-serine/threonine phosphatase.
Gene Ontology
Molecular Function
GO:0004722 protein serine/threonine phosphatase activity
GO:0043169 cation binding
Biological Process
GO:0006470 protein dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2p8e, PDBe:2p8e, PDBj:2p8e
PDBsum2p8e
PubMed18058037
UniProtO75688|PPM1B_HUMAN Protein phosphatase 1B (Gene Name=PPM1B)

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