Structure of PDB 2p5o Chain A Binding Site BS01

Receptor Information
>2p5o Chain A (length=856) Species: 12353 (Escherichia phage RB69) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKEFYLTVEQIGDSIFERYIDSNGRERTREVEYKPSLFAHCPESQATKYF
DIYGKPCTRKLFANMRDASQWIKRMEDIGLEALGMDDFKLAYLSDTYNYE
IKYDHTKIRVANFDIEVTSPDGFPEPSQAKHPIDAITHYDSIDDRFYVFD
LLNSPYGNVEEWSIEIAAKLQEQGGDEVPSEIIDKIIYMPFDNEKELLME
YLNFWQQKTPVILTGWNVESFAIPYVYNRIKNIFGESTAKRLSPHRKTRV
KVIENMYGSREIITLFGISVLDYIDLYKKFSFTNQPSYSLDYISEFELNV
GKLKYDGPISKLRESNHQRYISYNIIAVYRVLQIDAKRQFINLSLDMGYY
AKIQIQSVFSPIKTWDAIIFNSLKEQNKVIPQGRSHPVQPYPGAFVKEPI
PNRYKYVMSFDLTSLYPSIIRQVNISPETIAGTFKVAPLHDYINAVAERP
SDVYSCSPNGMMYYKDRDGVVPTEITKVFNQRKEHKGYMLAAQRMLFRAQ
RTEVAGMTAQINRKLLINSLYGALGNVWFRYYDLRNATAITTFGQMALQW
IERKVNEYLNEVCGTEGEAFVLYGDTDSIYVSADKIIDKVGESKFRDTNH
WVDFLDKFARERMEPAIDRGFREMCEYMNNKQHLMFMDREAIAGPPLGSK
GIGGFWTGKKRYALNVWDMEGTRYAEPKLKIMGLETQKSSTPKAVQKALK
ECIRRMLQEGEESLQEYFKEFEKEFRQLNYISIASVSSANNIAKYDVGGF
PGPKCPFHIRGILTYNRAIKGNIDAPQVVEGEKVYVLPLREGNPFGDKCI
AWPSGTEITDLIKDDVLHWMDYTVLLEKTFIKPLEGFTSAAKLDYEKKAS
LFDMFD
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2p5o Crystallographic snapshots of a replicative DNA polymerase encountering an abasic site.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		K251 I253 D275 F359 S360 P361 I362 G393 A394 V396 G568 N572 K705 K706 R707 K800 K844 K874
Binding residue
(residue number reindexed from 1)		K251 I253 D275 F359 S360 P361 I362 G393 A394 V396 G522 N526 K659 K660 R661 K754 K798 K828
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0004527 exonuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0039686 bidirectional double-stranded viral DNA replication
GO:0039693 viral DNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:2p5o, PDBe:2p5o, PDBj:2p5o
PDBsum2p5o
PubMed15057283
UniProtQ38087|DPOL_BPR69 DNA-directed DNA polymerase (Gene Name=43)

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