Structure of PDB 2p59 Chain A Binding Site BS01

Receptor Information

>2p59 Chain A (length=151) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

VEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTNV
DQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLS
PRPISYLKGSSGGPLLCPAGHAVGLFRAAVCTRGVAKAVDFIPVENLETT
M

Ligand information

>2p59 Chain C (length=16) Species: 63746 (Hepatitis C virus (isolate H77)) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

GSVVIVGRIVLSGKPA

Receptor-Ligand Complex Structure

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Structure summary

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PDB	2p59 Inhibitors of hepatitis C virus NS3.4A protease. Effect of P4 capping groups on inhibitory potency and pharmacokinetics.
Resolution	2.9 Å
Binding residue (original residue number in PDB)	V55 G57 E58 V59 I61 V62 S63 R88 T89 I90 A91 P114 G116
Binding residue (residue number reindexed from 1)	V1 G3 E4 V5 I7 V8 S9 R34 T35 I36 A37 P60 G62

Enzymatic activity

Catalytic site (original residue number in PDB)	H83 D107 G163 S165
Catalytic site (residue number reindexed from 1)	H29 D53 G109 S111
Enzyme Commision number	3.6.4.13: RNA helicase.

Gene Ontology

	Molecular Function
GO:0008233	peptidase activity
GO:0008236	serine-type peptidase activity
GO:0046872	metal ion binding

	Biological Process
GO:0006508	proteolysis
GO:0019062	virion attachment to host cell
GO:0019087	transformation of host cell by virus
GO:0046718	symbiont entry into host cell
GO:0097264	self proteolysis

	Cellular Component
GO:0016020	membrane
GO:0033644	host cell membrane
GO:0044423	virion component

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External links

PDB	RCSB:2p59, PDBe:2p59, PDBj:2p59
PDBsum	2p59
PubMed	17482818
UniProt	Q91RS4

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