Structure of PDB 2p39 Chain A Binding Site BS01

Receptor Information

>2p39 Chain A (length=142) Species: 9606 (Homo sapiens)

SPLLGSSWGGLIHLYTATARNSYHLQIHKNGHVDGAPHQTIYSALMIRSE
DAGFVVITGVMSRRYLCMDFRGNIFGSHYFDPENCRFQHQTLENGYDVYH
SPQYHFLVSLGRAKRAFLPGMNPPPYSQFLSRRNEIPLIHFN

Ligand information

• Ligand ID: GU4
• InChI: InChI=1S/C6H12O18S4/c7-6-5(24-28(17,18)19)4(23-27(14,15)16)3(22-26(11,12)13)2(21-6)1-20-25(8,9)10/h2-7H,1H2,(H,8,9,10)(H,11,12,13)(H,14,15,16)(H,17,18,19)/t2-,3-,4+,5-,6+/m1/s1
• InChIKey: SPIXVQOXHJQNTH-DVKNGEFBSA-N
• SMILES:
  OpenEye OEToolkits 2.0.7: C(C1C(C(C(C(O1)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O
  ACDLabs 12.01: OC1OC(COS(=O)(=O)O)C(OS(=O)(=O)O)C(OS(=O)(O)=O)C1OS(=O)(=O)O
  OpenEye OEToolkits 2.0.7: C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O
  CACTVS 3.385: O[CH]1O[CH](CO[S](O)(=O)=O)[CH](O[S](O)(=O)=O)[CH](O[S](O)(=O)=O)[CH]1O[S](O)(=O)=O
  CACTVS 3.385: O[C@H]1O[C@H](CO[S](O)(=O)=O)[C@@H](O[S](O)(=O)=O)[C@H](O[S](O)(=O)=O)[C@H]1O[S](O)(=O)=O
• Formula: C6 H12 O18 S4
• Name: 2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose;
  2,3,4,6-tetra-O-sulfonato-alpha-D-glucose;
  2,3,4,6-tetra-O-sulfonato-D-glucose;
  2,3,4,6-tetra-O-sulfonato-glucose
• ZINC: ZINC000058632064
• PDB chain: 2p39 Chain B Residue 1

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2p39 Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members.
• Resolution: 1.5 Å
• Binding residue (original residue number in PDB): R48 N49
• Binding residue (residue number reindexed from 1): R20 N21
• Annotation score: 1

Gene Ontology

Molecular Function

• GO:0008083 growth factor activity

External links

• PDB: RCSB:2p39, PDBe:2p39, PDBj:2p39
• PDBsum: 2p39
• PubMed: 17339340
• UniProt: Q9GZV9|FGF23_HUMAN Fibroblast growth factor 23 (Gene Name=FGF23)