Structure of PDB 2p1u Chain A Binding Site BS01

Receptor Information

>2p1u Chain A (length=211) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DMPVERILEAELAVEDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQ
VILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFD
RVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVY
ASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPI
DTFLMEMLEAP

Ligand information

>2p1u Chain B (length=10) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

HKILHRLLQD

Receptor-Ligand Complex Structure

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Structure summary

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PDB	2p1u Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function.
Resolution	2.2 Å
Binding residue (original residue number in PDB)	V280 K284 L294 V298 L301 R302 T449 F450 E453
Binding residue (residue number reindexed from 1)	V33 K37 L47 V51 L54 R55 T202 F203 E206

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003707	nuclear steroid receptor activity
GO:0008270	zinc ion binding

	Biological Process
GO:0006355	regulation of DNA-templated transcription

	Cellular Component
GO:0005634	nucleus

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Cellular Component

External links

PDB	RCSB:2p1u, PDBe:2p1u, PDBj:2p1u
PDBsum	2p1u
PubMed	17947383
UniProt	P19793\|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

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