Structure of PDB 2p0w Chain A Binding Site BS01

Receptor Information
>2p0w Chain A (length=319) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AEYKCNTNTAIELKLVRFPEDLENDIRTFFPEYTHQLFGDDETAFGYKGL
KILLYYIAGSLSTMFRVEYASKVDENFDCVEADDVEGKIRQIIPPGFCTN
TNDFLSLLEKEVDFKPFGTLLHTYSVLSPTGGENFTFQIYKADMTCRGFR
EYHERLQTFLMWFIETASFIDVDDERWHYFLVFEKYNKDGATLFATVGYM
TVYNYYVYPDKTRPRVSQMLILTPFQGQGHGAQLLETVHRYYTEFPTVLD
ITAEDPSKSYVKLRDFVLVKLCQDLPCFSREKLMQGFNEDMAIEAQQKFK
INKQHARRVYEILRLLVTD
Ligand information
Receptor-Ligand Complex Structure
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PDB2p0w The crystal structure of human histone acetyltransferase 1 (HAT1) in complex with acetylcoenzyme A and histone peptide H4
Resolution1.9 Å
Binding residue
(original residue number in PDB)		Y55 H57 Q58 D62 E64 I186 E187 T188 S190 W199 Y225 R237 S239 Q240 E276
Binding residue
(residue number reindexed from 1)		Y33 H35 Q36 D40 E42 I164 E165 T166 S168 W177 Y203 R215 S217 Q218 E254
Enzymatic activity
Catalytic site (original residue number in PDB) M241 E276
Catalytic site (residue number reindexed from 1) M219 E254
Enzyme Commision number 2.3.1.48: histone acetyltransferase.
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
GO:0042393 histone binding
Biological Process
GO:0006325 chromatin organization
GO:0031509 subtelomeric heterochromatin formation
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2p0w, PDBe:2p0w, PDBj:2p0w
PDBsum2p0w
PubMed
UniProtO14929|HAT1_HUMAN Histone acetyltransferase type B catalytic subunit (Gene Name=HAT1)

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