Structure of PDB 2oqr Chain A Binding Site BS01

Receptor Information

>2oqr Chain A (length=226) Species: 83332 (Mycobacterium tuberculosis H37Rv)

ATSVLIVEDEESLADPLAFLLRKEGFEATVVTDGPAALAEFDRAGADIVL
LDLMLPGMSGTDVCKQLRARSSVPVIMVTARDSEIDKVVGLELGADDYVT
KPYSARELIARIRAVLRRGGDDDSEMSDGVLESGPVRMDVERHVVSVNGD
TITLPLKEFDLLEYLMRNSGRVLTRGQLIDRVWGADYVGDTKTLDVHVKR
LRSKIEADPANPVHLVTVRGLGYKLE

Ligand information

• Ligand ID: LA
• InChI: InChI=1S/La/q+3
• InChIKey: CZMAIROVPAYCMU-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: [La+3]
• Formula: La
• Name: LANTHANUM (III) ION
• DrugBank: DB14579
• PDB chain: 2oqr Chain A Residue 301

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2oqr The Structure of a Full-length Response Regulator from Mycobacterium tuberculosis in a Stabilized Three-dimensional Domain-swapped, Activated State.
• Resolution: 2.03 Å
• Binding residue (original residue number in PDB): D86 D97 Y98
• Binding residue (residue number reindexed from 1): D86 D97 Y98
• Annotation score: 1

Gene Ontology

Molecular Function

• GO:0000156 phosphorelay response regulator activity
• GO:0000976 transcription cis-regulatory region binding
• GO:0003677 DNA binding

Biological Process

• GO:0000160 phosphorelay signal transduction system
• GO:0006355 regulation of DNA-templated transcription
• GO:0019220 regulation of phosphate metabolic process

Cellular Component

• GO:0005829 cytosol
• GO:0032993 protein-DNA complex

External links

• PDB: RCSB:2oqr, PDBe:2oqr, PDBj:2oqr
• PDBsum: 2oqr
• PubMed: 17942407
• UniProt: P9WGL9|REGX3_MYCTU Sensory transduction protein RegX3 (Gene Name=regX3)