Structure of PDB 2ood Chain A Binding Site BS01

Receptor Information

>2ood Chain A (length=463) Species: 224911 (Bradyrhizobium diazoefficiens USDA 110)

LTTVGIRGTFFDFVDDPWKHIGNEQAAARFHQDGLMVVTDGVIKAFGPYE
KIAAAHPGVEITHIKDRIIVPGFIDGHIHLPQTRVLGAYGEQLLPWLQKS
IYPEEIKYKDRNYAREGVKRFLDALLAAGTTTCQAFTSSSPVATEELFEE
ASRRNMRVIAGLTGIDRNAPAEFIDTPENFYRDSKRLIAQYHDKGRNLYA
ITPRFAFGASPELLKACQRLKHEHPDCWVNTHISENPAECSGVLVEHPDC
QDYLGVYEKFDLVGPKFSGGHGVYLSNNEFRRMSKKGAAVVFCPCSNLFL
GSGLFRLGRATDPEHRVKMSFGTDVGGGNRFSMISVLDDAYKVGMCNNTL
LDGSIDPSRKDLAEAERNKLSPYRGFWSVTLGGAEGLYIDDKLGNFEPGK
EADFVALDPNGGQLAQPWHQSLIGAGPRTVDEAASMLFAVMMVGDDRCVD
ETWVMGKRLYKKS

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 2ood Chain A Residue 500

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2ood Crystal structure of guanine deaminase from Bradyrhizobium japonicum
• Resolution: 2.62 Å
• Binding residue (original residue number in PDB): H79 H81 H234 D326
• Binding residue (residue number reindexed from 1): H77 H79 H232 D324
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.5.4.3: guanine deaminase.

Gene Ontology

Molecular Function

• GO:0008270 zinc ion binding
• GO:0008892 guanine deaminase activity
• GO:0016787 hydrolase activity
• GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
• GO:0046872 metal ion binding

Biological Process

• GO:0006147 guanine catabolic process
• GO:0046098 guanine metabolic process

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:2ood, PDBe:2ood, PDBj:2ood
• PDBsum: 2ood
• UniProt: Q89NG0