Structure of PDB 2oin Chain A Binding Site BS01

Receptor Information
>2oin Chain A (length=151) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTNV
DQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLS
PRPISYLKGSSGGPLLCPAGHAVGLFKAAVCTRGVAKAVDFIPVENLETT
M
Ligand information
>2oin Chain C (length=16) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GSVVIVGRIVLSGKPA
Receptor-Ligand Complex Structure
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PDB2oin Phenotypic and structural analyses of hepatitis C virus NS3 protease Arg155 variants: sensitivity to telaprevir (VX-950) and interferon alpha.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		V55 G57 E58 V59 Q60 I61 V62 S63 R88 T89 I90 A91 P114 G116
Binding residue
(residue number reindexed from 1)		V1 G3 E4 V5 Q6 I7 V8 S9 R34 T35 I36 A37 P60 G62
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

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Molecular Function
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Biological Process
External links
PDB RCSB:2oin, PDBe:2oin, PDBj:2oin
PDBsum2oin
PubMed17556358
UniProtP27958|POLG_HCV77 Genome polyprotein

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