Structure of PDB 2odp Chain A Binding Site BS01

Receptor Information

>2odp Chain A (length=490) Species: 9606 (Homo sapiens)

KIQIQRSGHLNLYLLLDASQSVSENDFLIFKESASLMVDRIFSFEINVSV
AIITFASEPKVLMSVLNDNSRDMTEVISSLENANYKDHENGTGTNTYAAL
NSVYLMMNNQMRLLGMETMAWQEIRHAIILLTDGKSNMGGSPKTAVDHIR
EILNINQKRNDYLDIYAIGVGKLDVDWRELNELGSKKDGERHAFILQDTK
ALHQVFEHMLDVSKLTDTICGVGNMSANASDQERTPWHVTIKPTCRGALI
SDQWVLTAAHCFWRVNVGDPKSQWGKEFLIEKAVISPGFDVFAKKNQGIL
EFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLALRRPQGSTCRDHEN
ELLNKQSVPAHFVALNGSKLNINLKMGVEWTSCAEVVSQEKTMFPNLTDV
REVVTDQFLCSGTQEDESPCKGESGGAVFLERRFRFFQVGLVSWGLYNPC
LNSRKRAPRSKVPPPRDFHINLFRMQPWLRQHLGDVLNFL

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 2odp Chain A Residue 901

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2odp The crystal structure of c2a, the catalytic fragment of classical pathway c3 and c5 convertase of human complement.
• Resolution: 1.9 Å
• Binding residue (original residue number in PDB): S242 S244 T317
• Binding residue (residue number reindexed from 1): S19 S21 T94
• Annotation score: 4

Enzymatic activity

• Catalytic site (original residue number in PDB): H487 D541 S659
• Catalytic site (residue number reindexed from 1): H260 D306 S424
• Enzyme Commision number: 3.4.21.43: classical-complement-pathway C3/C5 convertase.

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity

Biological Process

• GO:0006508 proteolysis
• GO:0006956 complement activation

Cellular Component

• GO:0005576 extracellular region

External links

• PDB: RCSB:2odp, PDBe:2odp, PDBj:2odp
• PDBsum: 2odp
• PubMed: 17234210
• UniProt: Q5JP69