Structure of PDB 2od7 Chain A Binding Site BS01

Receptor Information
>2od7 Chain A (length=289) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MASMSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSP
GTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFH
YLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCG
KVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWL
NDSEWLREKIQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGD
FKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2od7 Structural basis for nicotinamide inhibition and base exchange in sir2 enzymes.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		E64 H135 V182 F184 G185 E186 D187 D190 S193 A227 V228 Y229 P230
Binding residue
(residue number reindexed from 1)		E67 H138 V185 F187 G188 E189 D190 D193 S196 A223 V224 Y225 P226
Enzymatic activity
Catalytic site (original residue number in PDB) P42 D43 F44 R45 N116 D118 H135
Catalytic site (residue number reindexed from 1) P45 D46 F47 R48 N119 D121 H138
Enzyme Commision number 2.3.1.286: protein acetyllysine N-acetyltransferase.
Gene Ontology
Molecular Function
GO:0017136 NAD-dependent histone deacetylase activity
GO:0051287 NAD binding
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:2od7, PDBe:2od7, PDBj:2od7
PDBsum2od7
PubMed17289592
UniProtP53686|HST2_YEAST NAD-dependent protein deacetylase HST2 (Gene Name=HST2)

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