Structure of PDB 2od2 Chain A Binding Site BS01

Receptor Information
>2od2 Chain A (length=291) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MASMSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSP
GTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFH
YLLKLFQDKDVLKRVYTQNFDTLERQAGVKDDLIIEAHGSFAHCHCIGCG
KVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWL
NDSEWLREKITTQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETV
GDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB2od2 Structural basis for nicotinamide inhibition and base exchange in sir2 enzymes.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		E64 V182 F184 G185 E186 D187 P189 S193 A227 V228 Y229
Binding residue
(residue number reindexed from 1)		E67 V185 F187 G188 E189 D190 P192 S196 A225 V226 Y227
Enzymatic activity
Catalytic site (original residue number in PDB) P42 D43 F44 R45 N116 D118 H135
Catalytic site (residue number reindexed from 1) P45 D46 F47 R48 N119 D121 H138
Enzyme Commision number 2.3.1.286: protein acetyllysine N-acetyltransferase.
Gene Ontology
Molecular Function
GO:0017136 NAD-dependent histone deacetylase activity
GO:0051287 NAD binding
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:2od2, PDBe:2od2, PDBj:2od2
PDBsum2od2
PubMed17289592
UniProtP53686|HST2_YEAST NAD-dependent protein deacetylase HST2 (Gene Name=HST2)

[Back to BioLiP]