Structure of PDB 2o59 Chain A Binding Site BS01

Receptor Information
>2o59 Chain A (length=619) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQ
PDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVH
AGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLR
SNSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQT
PVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSCEPYQDE
EGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAA
KRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAIS
VHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKV
YNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGS
KNDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFV
QDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKAL
FHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAK
RTPVRQFRGIGAIAHHHHH
Ligand information
Receptor-Ligand Complex Structure
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PDB2o59 Structural Studies of E. coli Topoisomerase III-DNA Complexes Reveal a Novel Type IA Topoisomerase-DNA Conformational Intermediate.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		Q50 P51 W61 E107 R165 D169 W170 G173 I174 T177 R178 R185 S194 G196 R197 V198 Q199 R330 T524 T527 R538
Binding residue
(residue number reindexed from 1)		Q50 P51 W61 E107 R165 D169 W170 G173 I174 T177 R178 R185 S194 G196 R197 V198 Q199 R328 T517 T520 R531
Enzymatic activity
Catalytic site (original residue number in PDB) E7 D105 E107
Catalytic site (residue number reindexed from 1) E7 D105 E107
Enzyme Commision number 5.6.2.1: DNA topoisomerase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003916 DNA topoisomerase activity
GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity
GO:0005515 protein binding
GO:0046872 metal ion binding
GO:0098847 sequence-specific single stranded DNA binding
Biological Process
GO:0006261 DNA-templated DNA replication
GO:0006265 DNA topological change
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0051304 chromosome separation
Cellular Component
GO:0043597 cytoplasmic replication fork

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2o59, PDBe:2o59, PDBj:2o59
PDBsum2o59
PubMed17331537
UniProtP14294|TOP3_ECOLI DNA topoisomerase 3 (Gene Name=topB)

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