Structure of PDB 2o4c Chain A Binding Site BS01

Receptor Information
>2o4c Chain A (length=380) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MRILADENIPVVDAFFADQGSIRRLPGRAIDRAALAEVDVLLVRSVTEVS
RAALAGSPVRFVGTCTIGTDHLDLDYFAEAGIAWSSAPGCNARGVVDYVL
GCLLAMAEVRGADLAERTYGVVGAGQVGGRLVEVLRGLGWKVLVCDPPRQ
AREPDGEFVSLERLLAEADVISLHTPLNRDGEHPTRHLLDEPRLAALRPG
TWLVNASRGAVVDNQALRRLLEGGADLEVALDVWEGEPQADPELAARCLI
ATPHIAGYSLEGKLRGTAQIYQAYCAWRGIAERVSLQDVLPETWLAGLQL
NPGCDPAWALATLCRAVYDPRSDDAAFRRSLTGDSATRRAAFDALRKHYP
PRREITGLRVATGGQAELQRVVRALGAQLV
Ligand information
Ligand IDPO4
InChIInChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
InChIKeyNBIIXXVUZAFLBC-UHFFFAOYSA-K
SMILES
SoftwareSMILES
CACTVS 3.341[O-][P]([O-])([O-])=O
ACDLabs 10.04[O-]P([O-])([O-])=O
OpenEye OEToolkits 1.5.0[O-]P(=O)([O-])[O-]
FormulaO4 P
NamePHOSPHATE ION
ChEMBL
DrugBankDB14523
ZINC
PDB chain2o4c Chain A Residue 900 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB2o4c Crystal Structure of d-Erythronate-4-phosphate Dehydrogenase Complexed with NAD
Resolution2.3 Å
Binding residue
(original residue number in PDB)		T66 R346
Binding residue
(residue number reindexed from 1)		T66 R346
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) N91 R208 D232 E237 H254
Catalytic site (residue number reindexed from 1) N91 R208 D232 E237 H254
Enzyme Commision number 1.1.1.290: 4-phosphoerythronate dehydrogenase.
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0033711 4-phosphoerythronate dehydrogenase activity
GO:0046983 protein dimerization activity
GO:0051287 NAD binding
Biological Process
GO:0008615 pyridoxine biosynthetic process
GO:0036001 'de novo' pyridoxal 5'-phosphate biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2o4c, PDBe:2o4c, PDBj:2o4c
PDBsum2o4c
PubMed17217963
UniProtQ9I3W9|PDXB_PSEAE Erythronate-4-phosphate dehydrogenase (Gene Name=pdxB)

[Back to BioLiP]