Structure of PDB 2o0r Chain A Binding Site BS01

Receptor Information
>2o0r Chain A (length=385) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ATVSRLRPYATTVFAEMSALATRIGAVNLGQGFPDEDGPPKMLQAAQDAI
AGGVNQYPPGPGSAPLRRAIAAQRRRHFGVDYDPETEVLVTVGATEAIAA
AVLGLVEPGSEVLLIEPFYDSYSPVVAMAGAHRVTVPLVPDGRGFALDAD
ALRRAVTPRTRALIINSPHNPTGAVLSATELAAIAEIAVAANLVVITDEV
YEHLVFDHARHLPLAGFDGMAERTITISSAAKMFNCTGWKIGWACGPAEL
IAGVRAAKQYLSYVGGAPFQPAVALALDTEDAWVAALRNSLRARRDRLAA
GLTEIGFAVHDSYGTYFLCADPRPLGYDDSTEFCAALPEKVGVAAIPMSA
FCDPADVWNHLVRFTFCKRDDTLDEAIRRLSVLAE
Ligand information
Ligand IDGOL
InChIInChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2
InChIKeyPEDCQBHIVMGVHV-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0C(C(CO)O)O
ACDLabs 12.01
CACTVS 3.370		OCC(O)CO
FormulaC3 H8 O3
NameGLYCEROL;
GLYCERIN;
PROPANE-1,2,3-TRIOL
ChEMBLCHEMBL692
DrugBankDB09462
ZINCZINC000000895048
PDB chain2o0r Chain A Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2o0r The Three-dimensional Structure of N-Succinyldiaminopimelate Aminotransferase from Mycobacterium tuberculosis
Resolution2.0 Å
Binding residue
(original residue number in PDB)		F14 D120
Binding residue
(residue number reindexed from 1)		F14 D120
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) Y119 D198 V200 K232
Catalytic site (residue number reindexed from 1) Y119 D198 V200 K232
Enzyme Commision number 2.6.1.17: succinyldiaminopimelate transaminase.
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008483 transaminase activity
GO:0009016 succinyldiaminopimelate transaminase activity
GO:0016212 kynurenine-oxoglutarate transaminase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0009058 biosynthetic process
GO:0009085 lysine biosynthetic process
GO:0009089 lysine biosynthetic process via diaminopimelate
Cellular Component
GO:0005737 cytoplasm
GO:0009274 peptidoglycan-based cell wall

View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2o0r, PDBe:2o0r, PDBj:2o0r
PDBsum2o0r
PubMed17292400
UniProtP9WPZ5|DAPC_MYCTU Probable N-succinyldiaminopimelate aminotransferase DapC (Gene Name=dapC)

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