Structure of PDB 2nxf Chain A Binding Site BS01

Receptor Information
>2nxf Chain A (length=314) Species: 7955 (Danio rerio) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DPVFTFGLIADVQYADIEDGENYLRTRRRYYRGSADLLRDAVLQWRRERV
QCVVQLGDIIDGHNRRRDASDRALDTVMAELDACSVDVHHVWGNHEFYNF
SRPSLLSSRLNSAQGSDLIGDDIYAYEFSPAPNFRFVLLDAYDLSVIGRE
EESEKHTHSWRILTQHNHNLQDLNLPPVSVGLEQRFVKFNGGFSEQQLQW
LDAVLTLSDHKQERVLIFSHLPVHPCAADPICLAWNHEAVLSVLRSHQSV
LCFIAGHDHDGGRCTDSSGAQHITLEGVIETPPHSHAFATAYLYEDRMVM
KGRGRVEDLTITYS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2nxf Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2nxf Crystal Structure of a dimetal phosphatase from Danio rerio LOC 393393
Resolution1.7 Å
Binding residue
(original residue number in PDB)		D13 Q15 D60 H267
Binding residue
(residue number reindexed from 1)		D11 Q13 D58 H259
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.1.13: ADP-ribose diphosphatase.
3.6.1.16: CDP-glycerol diphosphatase.
3.6.1.53: Mn(2+)-dependent ADP-ribose/CDP-alcohol diphosphatase.
Gene Ontology
Molecular Function
GO:0008663 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity
GO:0016787 hydrolase activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
GO:0047631 ADP-ribose diphosphatase activity
GO:0047734 CDP-glycerol diphosphatase activity
Cellular Component
GO:0005575 cellular_component

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Molecular Function
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Cellular Component
External links
PDB RCSB:2nxf, PDBe:2nxf, PDBj:2nxf
PDBsum2nxf
PubMed
UniProtQ7T291|ADPRM_DANRE Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase (Gene Name=adprm)

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