Structure of PDB 2nx8 Chain A Binding Site BS01

Receptor Information
>2nx8 Chain A (length=168) Species: 301450 (Streptococcus pyogenes serotype M6) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SFLMPYSLEEQTYFMQEALKESEKSLQKAEIPIGCVIVKDGEIIGRGHNA
REESNQAIMHAEMMAINEANAHEGNWRLLDTTLFVTIEPCVMCSGAIGLA
RIPHVIYGASNQKFGGVDSLYQILTDERLNHRVQVERGLLAADCANIMQT
FFRQGRERKKIAKHLIKE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2nx8 Chain A Residue 999 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2nx8 Crystal structure of the tRNA-specific adenosine deaminase from Streptococcus pyogenes
Resolution2.0 Å
Binding residue
(original residue number in PDB)		H65 C95 C98
Binding residue
(residue number reindexed from 1)		H60 C90 C93
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H65 E67 E93 C95 C98
Catalytic site (residue number reindexed from 1) H60 E62 E88 C90 C93
Enzyme Commision number 3.5.4.33: tRNA(adenine(34)) deaminase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008251 tRNA-specific adenosine deaminase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0052717 tRNA-specific adenosine-34 deaminase activity
Biological Process
GO:0002100 tRNA wobble adenosine to inosine editing
GO:0008033 tRNA processing

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Molecular Function
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Biological Process
External links
PDB RCSB:2nx8, PDBe:2nx8, PDBj:2nx8
PDBsum2nx8
PubMed17554781
UniProtQ5XE14|TADA_STRP6 tRNA-specific adenosine deaminase (Gene Name=tadA)

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