Structure of PDB 2nvo Chain A Binding Site BS01

Receptor Information

>2nvo Chain A (length=496) Species: 1299 (Deinococcus radiodurans)

SDESRLTRFLVLGVDGGTFYASAQKHTVQATDFVRELVQRDAALALRVTL
DVVRGQRAPKADPALLVLALIAKTAPNAADRKAAWDALPEVARTGTMLLH
FLAFADALGGWGRLTRRGVANVYETADVDKLALWAVKYKARDGWSQADAL
RKAHPKTDDAARNAVLKFMVDGVLPKVDSPALRVIEGHLKATEAQTDAAA
AALMQEYRLPLEAVPTHVRGAEVYRAAMQTNGLTWLLRNLGNLGRVGVLT
PNDSATVQAVIERLTDPAALKRGRIHPLDALKARLVYAQGQGVRGKGTWL
PVPRVVDALEEAFTLAFGNVQPANTRHLLALDVSGSMTCGDVAGVPGLTP
NMAAAAMSLIALRTEPDALTMGFAEQFRPLGITPRDTLESAMQKAQSVSF
GGTDCAQPILWAAQERLDVDTFVVYTDNETWAGQVHPTVALDQYAQKMGR
APKLIVVGLTATEFSIADPQRRDMLDVVGFDAAAPNVMTAFARGEV

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 2nvo Chain A Residue 533

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2nvo Crystal structure of Rsr, an ortholog of the antigenic Ro protein, links conformational flexibility to RNA binding activity.
• Resolution: 1.89 Å
• Binding residue (original residue number in PDB): S369 S371 E464
• Binding residue (residue number reindexed from 1): S334 S336 E429
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0005515 protein binding
• GO:0046872 metal ion binding

Cellular Component

• GO:0005737 cytoplasm
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:2nvo, PDBe:2nvo, PDBj:2nvo
• PDBsum: 2nvo
• PubMed: 17392270
• UniProt: Q9RUW8|RO60_DEIRA RNA-binding protein RO60 (Gene Name=rsr)