Structure of PDB 2npi Chain A Binding Site BS01

Receptor Information
>2npi Chain A (length=428) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TGDNEWHKLVIPKGSDWQIDLKAEGKLIVKVNSGIVEIFGTELAVDDEYT
FQNWKFPIYAVEETELLWKCPDLTTNTITVKPNHTMKYIYNLHFMLEKIR
MSNFEGPRVVIVGGSQTGKTSLSRTLCSYALKFNAYQPLYINLDPQQPIF
TVPGCISATPISDILDAQLPTWGQSLTSGATLLHNKQPMVKNFGLERINE
NKDLYLECISQLGQVVGQRLHLDPQVRRSGCIVDTPSISQLDENLAELHH
IIEKLNVNIMLVLCSETDPLWEKVKKTFGPELGNNNIFFIPKLDGVSAVD
DVYKRSLQRTSIREYFYGSLDTALSPYAIGVDYEDLTIWKPSNVFDNEVG
RVELFPVTITPSNLQHAIIAITFAERRADQATVIKSPILGFALITEVNEK
RRKLRVLLPVPGRLPSKAMILTSYRYLE
Ligand information
>2npi Chain C (length=22) Species: 4932 (Saccharomyces cerevisiae) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
IQSRNWYLSDSQWAAFKDDEIT
Receptor-Ligand Complex Structure
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PDB2npi Structure of a nucleotide-bound Clp1-Pcf11 polyadenylation factor
Resolution2.95 Å
Binding residue
(original residue number in PDB)		S179 Q191 S192 L193 T194 S195 G196 Q204 M206 K208 V232 Q235 R236 L239 E331 Y332 L341 S342 I388 F390 P404 L406 G407 P426 V427 P428 P432
Binding residue
(residue number reindexed from 1)		S162 Q174 S175 L176 T177 S178 G179 Q187 M189 K191 V215 Q218 R219 L222 E314 Y315 L324 S325 I371 F373 P387 L389 G390 P409 V410 P411 P415
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0051731 polynucleotide 5'-hydroxyl-kinase activity
Biological Process
GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation
GO:0006396 RNA processing
GO:0006397 mRNA processing
GO:0031124 mRNA 3'-end processing
Cellular Component
GO:0005634 nucleus
GO:0005849 mRNA cleavage factor complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2npi, PDBe:2npi, PDBj:2npi
PDBsum2npi
PubMed17151076
UniProtQ08685|CLP1_YEAST mRNA cleavage and polyadenylation factor CLP1 (Gene Name=CLP1)

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