Structure of PDB 2nce Chain A Binding Site BS01

Receptor Information
>2nce Chain A (length=139) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HTEKRGRIYLKAEVTDEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDP
KNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTRND
FMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEG
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain2nce Chain A Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2nce Ca2+-sensing domain contributes to auto-inhibition of protein kinase Calpha through interactions with C-terminal tail
ResolutionN/A
Binding residue
(original residue number in PDB)		D187 D193 D246 W247 D248
Binding residue
(residue number reindexed from 1)		D33 D39 D92 W93 D94
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.11.13: protein kinase C.
External links
PDB RCSB:2nce, PDBe:2nce, PDBj:2nce
PDBsum2nce
PubMed
UniProtP05696|KPCA_RAT Protein kinase C alpha type (Gene Name=Prkca)

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