Structure of PDB 2ms1 Chain A Binding Site BS01

Receptor Information
>2ms1 Chain A (length=55) Species: 11786 (Murine leukemia virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ATVVSGQKQDRQGGERRRSQLDRDQCAYCKEKGHWAKDCPKKPRGPRGPR
PQTSL
Ligand information
>2ms1 Chain B (length=71) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggcucguuggucuagggguaugauucucgcuuagggugcgagaggucccg
gguucaaaucccggacgagcc
<<<<<....<<<.........>>><<<<<<.......>>>>>>....<<<
<<.......>>>>>..>>>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2ms1 A structure-based mechanism for tRNA and retroviral RNA remodelling during primer annealing.
ResolutionN/A
Binding residue
(original residue number in PDB)		R17 R18 D22 R23 Q25 A27 Y28 K30 W35 A36 K41 K42
Binding residue
(residue number reindexed from 1)		R17 R18 D22 R23 Q25 A27 Y28 K30 W35 A36 K41 K42
Binding affinityPDBbind-CN: Kd=4nM
Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.26.4: ribonuclease H.
3.4.23.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:2ms1, PDBe:2ms1, PDBj:2ms1
PDBsum2ms1
PubMed25209668
UniProtP03355|POL_MLVMS Gag-Pol polyprotein (Gene Name=gag-pol)

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