Structure of PDB 2m9p Chain A Binding Site BS01

Receptor Information
>2m9p Chain A (length=240) Species: 413041 (Dengue virus 2 Thailand/0168/1979) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSAADLELERAADVKWEDQAEISGSSPILSITISEDGSMSIKNEEEEQTL
GGGGSGGGGEFAGVLWDVPSPPPVGKAELEDGAYRIKQKGILGYSQIGAG
VYKEGTFHTMWHVTRGAVLMHKGKRIEPSWADVKKDLISYGGGWKLEGEW
KEGEEVQVLALEPGKNPRAVQTKPGLFKTNAGTIGAVSLDFSPGTSGSPI
IDKKGKVVGLYGNGVVTRSGAYVSAIAQTEKSIEDNPEIE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2m9p NMR structure of an inhibitor bound dengue NS3 protease provides new insights into the NS2B NS3 ligand interactions
ResolutionN/A
Binding residue
(original residue number in PDB)		E44 E45 E46 E47 Q48 T49 I97 H112 V113 S196 G212 V215 V216 S219 S224
Binding residue
(residue number reindexed from 1)		E44 E45 E46 E47 Q48 T49 I97 H112 V113 S196 G212 V215 V216 S219 S224
Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0004252 serine-type endopeptidase activity
GO:0005524 ATP binding
Cellular Component
GO:0044423 virion component

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Molecular Function
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Cellular Component
External links
PDB RCSB:2m9p, PDBe:2m9p, PDBj:2m9p
PDBsum2m9p
PubMed
UniProtP14337|POLG_DEN28 Genome polyprotein

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