Structure of PDB 2m0p Chain A Binding Site BS01

Receptor Information
>2m0p Chain A (length=46) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
THAPASCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNCNSTET
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain2m0p Chain A Residue 1201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2m0p Gentamicin binds to the megalin receptor as a competitive inhibitor using the common ligand binding motif of complement type repeats: insight from the nmr structure of the 10th complement type repeat domain alone and in complex with gentamicin.
ResolutionN/A
Binding residue
(original residue number in PDB)		W1126 D1129 D1131 D1133 D1139 E1140
Binding residue
(residue number reindexed from 1)		W24 D27 D29 D31 D37 E38
Annotation score4
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:2m0p, PDBe:2m0p, PDBj:2m0p
PDBsum2m0p
PubMed23275343
UniProtP98164|LRP2_HUMAN Low-density lipoprotein receptor-related protein 2 (Gene Name=LRP2)

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