Structure of PDB 2lkx Chain A Binding Site BS01
Receptor Information
>2lkx Chain A (length=68) Species:
9606
(Homo sapiens) [
Search protein sequence
] [
Download receptor structure
] [
Download structure with residue number starting from 1
] [
View receptor structure
]
GSQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVW
FKNRRAKWRKREEFIVTD
Ligand information
>2lkx Chain B (length=13) [
Search DNA sequence
] [
Download ligand structure
] [
Download structure with residue number starting from 1
] [
View ligand structure
]
gctctaatccccg
Receptor-Ligand Complex Structure
Global view
Local view
Structure summary
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
PDB
2lkx
Solution structure of the K50 class homeodomain PITX2 bound to DNA and implications for mutations that cause Rieger syndrome
Resolution
N/A
Binding residue
(original residue number in PDB)
R3 R5 T6 K50 N51 R52 K55 R59
Binding residue
(residue number reindexed from 1)
R5 R7 T8 K52 N53 R54 K57 R61
Binding affinity
PDBbind-CN
: Kd=2.6nM
Enzymatic activity
Enzyme Commision number
?
Gene Ontology
Molecular Function
GO:0000981
DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003677
DNA binding
Biological Process
GO:0006355
regulation of DNA-templated transcription
View graph for
Molecular Function
View graph for
Biological Process
External links
PDB
RCSB:2lkx
,
PDBe:2lkx
,
PDBj:2lkx
PDBsum
2lkx
PubMed
15895993
UniProt
Q99697
|PITX2_HUMAN Pituitary homeobox 2 (Gene Name=PITX2)
[
Back to BioLiP
]