Structure of PDB 2lb2 Chain A Binding Site BS01
Receptor Information
>2lb2 Chain A (length=35) Species:
9606
(Homo sapiens) [
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GLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQL
Ligand information
>2lb2 Chain B (length=12) Species:
9606
(Homo sapiens) [
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ETPPPGYLSEDG
Receptor-Ligand Complex Structure
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PDB
2lb2
A Smad action turnover switch operated by WW domain readers of a phosphoserine code.
Resolution
N/A
Binding residue
(original residue number in PDB)
E372 E373 R374 K378 R380 Y382 V384 N385 H386 R389 T390 T391 W393
Binding residue
(residue number reindexed from 1)
E7 E8 R9 K13 R15 Y17 V19 N20 H21 R24 T25 T26 W28
Enzymatic activity
Enzyme Commision number
2.3.2.26
: HECT-type E3 ubiquitin transferase.
2.3.2.36
: RING-type E3 ubiquitin transferase (cysteine targeting).
External links
PDB
RCSB:2lb2
,
PDBe:2lb2
,
PDBj:2lb2
PDBsum
2lb2
PubMed
21685363
UniProt
Q96PU5
|NED4L_HUMAN E3 ubiquitin-protein ligase NEDD4-like (Gene Name=NEDD4L)
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