Structure of PDB 2l6l Chain A Binding Site BS01

Receptor Information

>2l6l Chain A (length=155) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MMAVEQMPKKDWYSILGADPSANISDLKQKYQKLILMYHPDKQSTDVPAG
TVEECVQKFIEIDQAWKILGNEETKREYDLQRCEDDLRNVGPVDAQVYLE
EMSWNEGDHSFYLSCRCGGKYSVSKDEAEEVSLISCDTCSLIIELLHYNH
HHHHH

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

2l6l Chain A Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	2l6l Structure and mechanistic insights into novel iron-mediated moonlighting functions of human J-protein cochaperone, Dph4.
Resolution	N/A
Binding residue (original residue number in PDB)	C115 C136
Binding residue (residue number reindexed from 1)	C115 C136
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0001671	ATPase activator activity
GO:0008198	ferrous iron binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

	Biological Process
GO:0017183	protein histidyl modification to diphthamide
GO:0032781	positive regulation of ATP-dependent activity
GO:0061077	chaperone-mediated protein folding

	Cellular Component
GO:0005737	cytoplasm
GO:0005856	cytoskeleton

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:2l6l, PDBe:2l6l, PDBj:2l6l
PDBsum	2l6l
PubMed	22367199
UniProt	Q6P3W2\|DJC24_HUMAN DnaJ homolog subfamily C member 24 (Gene Name=DNAJC24)

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