Structure of PDB 2l5y Chain A Binding Site BS01

Receptor Information
>2l5y Chain A (length=150) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSHMASTEEDRFSLEALQTIHKQMDDDKDGGIEVEESDEFIREDMKYKDA
TNKHSHLHREDKHITIEDLWKRWKTSEVHNWTLEDTLQWLIEFVELPQYE
KNFRDNNVKGTTLPRIAVHEPSFMISQLKISDRSHRQKLQLKALDVVLFG
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain2l5y Chain A Residue 300 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2l5y Auto-inhibitory role of the EF-SAM domain of STIM proteins in store-operated calcium entry.
ResolutionN/A
Binding residue
(original residue number in PDB)		D80 D82 D84 G86 E88 E91
Binding residue
(residue number reindexed from 1)		D25 D27 D29 G31 E33 E36
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005246 calcium channel regulator activity
Biological Process
GO:0006874 intracellular calcium ion homeostasis

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Molecular Function
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Biological Process
External links
PDB RCSB:2l5y, PDBe:2l5y, PDBj:2l5y
PDBsum2l5y
PubMed21217057
UniProtQ9P246|STIM2_HUMAN Stromal interaction molecule 2 (Gene Name=STIM2)

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