Structure of PDB 2l4l Chain A Binding Site BS01

Receptor Information
>2l4l Chain A (length=45) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KNVKCFNCGKEGHTARNCRAPRKKGCWKCGKEGHQMKDCTERQAN
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2l4l Structural insights into the cTAR DNA recognition by the HIV-1 nucleocapsid protein: role of sugar deoxyriboses in the binding polarity of NC.
ResolutionN/A
Binding residue
(original residue number in PDB)		F16 T24 R26 K33 C36 W37 Q45 M46
Binding residue
(residue number reindexed from 1)		F6 T14 R16 K23 C26 W27 Q35 M36
Binding affinityPDBbind-CN: Kd=1.6uM
Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:2l4l, PDBe:2l4l, PDBj:2l4l
PDBsum2l4l
PubMed21227929
UniProtP03366|POL_HV1B1 Gag-Pol polyprotein (Gene Name=gag-pol)

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