Structure of PDB 2ksa Chain A Binding Site BS01

Receptor Information

>2ksa Chain A (length=363) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNV
VVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYG
LFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVI
CVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVT
VLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMI
VVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYN
PIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKV
SRLETTISTVVGA

Ligand information

>2ksa Chain B (length=11) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

RPKPQQFFGLM

Receptor-Ligand Complex Structure

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Structure summary

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PDB	2ksa NMR evidence of GM1-induced conformational change of Substance P using isotropic bicelles
Resolution	N/A
Binding residue (original residue number in PDB)	D10 S16 T19
Binding residue (residue number reindexed from 1)	D9 S15 T18

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0004930	G protein-coupled receptor activity
GO:0004995	tachykinin receptor activity

	Biological Process
GO:0007186	G protein-coupled receptor signaling pathway

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane

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Cellular Component

External links

PDB	RCSB:2ksa, PDBe:2ksa, PDBj:2ksa
PDBsum	2ksa
PubMed	20937248
UniProt	P25103\|NK1R_HUMAN Substance-P receptor (Gene Name=TACR1)

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