Structure of PDB 2kqe Chain A Binding Site BS01

Receptor Information
>2kqe Chain A (length=47) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GGVQIVGQDETDDRPECPYGPSCYRKNPQHKIEYRHNTLPVRNVLDE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2kqe Chain A Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2kqe Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose).
ResolutionN/A
Binding residue
(original residue number in PDB)		C421 C427 H434 H440
Binding residue
(residue number reindexed from 1)		C17 C23 H30 H36
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0006302 double-strand break repair

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Molecular Function
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Biological Process
External links
PDB RCSB:2kqe, PDBe:2kqe, PDBj:2kqe
PDBsum2kqe
PubMed20098424
UniProtQ8IW19|APLF_HUMAN Aprataxin and PNK-like factor (Gene Name=APLF)

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