Structure of PDB 2k60 Chain A Binding Site BS01

Receptor Information
>2k60 Chain A (length=150) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSHMASSEDEKLSFEAVRNIHKLMDDDANGDVDVEESDEFLREDLNYHDP
TVKHSTFHGEDKLISVEDLWKAWKSSEVYNWTVDEVVQWLITYVELPQYE
ETFRKLQLSGHAMPRLAVTNTTMTGTVLKMTDRSHRQKLQLKALDTVLFG
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain2k60 Chain A Residue 686 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2k60 Structural and mechanistic insights into STIM1-mediated initiation of store-operated calcium entry.
ResolutionN/A
Binding residue
(original residue number in PDB)		D76 D78 N80 D82 E87
Binding residue
(residue number reindexed from 1)		D25 D27 N29 D31 E36
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005246 calcium channel regulator activity
Biological Process
GO:0032237 activation of store-operated calcium channel activity

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Molecular Function
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Biological Process
External links
PDB RCSB:2k60, PDBe:2k60, PDBj:2k60
PDBsum2k60
PubMed18854159
UniProtQ13586|STIM1_HUMAN Stromal interaction molecule 1 (Gene Name=STIM1)

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