Structure of PDB 2k1q Chain A Binding Site BS01

Receptor Information
>2k1q Chain A (length=165) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TGRDKNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPI
TQMYTNVDQDLVGWQAPPGARSLTPCTCGSSDLYLVTRHADVIPVRRRGD
SRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVP
VESMETTMRASKKKK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2k1q Binding of a noncovalent inhibitor exploiting the S' region stabilizes the hepatitis C virus NS3 protease conformation in the absence of cofactor.
ResolutionN/A
Binding residue
(original residue number in PDB)		Q41 S42 H57 G58 V132 L135 K136 G137 S139 A156 A157
Binding residue
(residue number reindexed from 1)		Q20 S21 H36 G37 V111 L114 K115 G116 S118 A135 A136
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D81 G137 S139
Catalytic site (residue number reindexed from 1) H36 D60 G116 S118
Enzyme Commision number 3.4.21.98: hepacivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

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Molecular Function
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Biological Process
External links
PDB RCSB:2k1q, PDBe:2k1q, PDBj:2k1q
PDBsum2k1q
PubMed19061898
UniProtP90191

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