Structure of PDB 2jxc Chain A Binding Site BS01

Receptor Information
>2jxc Chain A (length=95) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PWAVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWE
LSDIDHDGMLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKR
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain2jxc Chain A Residue 1000 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB2jxc Structure of the Eps15-stonin2 complex provides a molecular explanation for EH-domain ligand specificity.
ResolutionN/A
Binding residue
(original residue number in PDB)		D173 D175 D177 M179 E184
Binding residue
(residue number reindexed from 1)		D53 D55 D57 M59 E64
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding

View graph for
Molecular Function
External links
PDB RCSB:2jxc, PDBe:2jxc, PDBj:2jxc
PDBsum2jxc
PubMed18200045
UniProtP42566|EPS15_HUMAN Epidermal growth factor receptor substrate 15 (Gene Name=EPS15)

[Back to BioLiP]