Structure of PDB 2jul Chain A Binding Site BS01

Receptor Information
>2jul Chain A (length=181) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PEGLDQLQAQTKFTKKELQSLYRGFKNECPTGLVDEDTFKLIYSQFFPQG
DATTYAHFLFNAFDADGNGAIHFEDFVVGLSILLRGTVHEKLKWAFNLYD
INKDGCITKEEMLAIMKSIYDMMGRHTYPILREDAPLEHVERFFQKMDRN
QDGVVTIDEFLETCQKDENIMNSMQLFENVI
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain2jul Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2jul NMR structure of DREAM: Implications for Ca(2+)-dependent DNA binding and protein dimerization.
ResolutionN/A
Binding residue
(original residue number in PDB)		D175 N177 D179 C181 E186
Binding residue
(residue number reindexed from 1)		D100 N102 D104 C106 E111
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0001046 core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0005267 potassium channel activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0015459 potassium channel regulator activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0006813 potassium ion transport
GO:0006915 apoptotic process
GO:0019233 sensory perception of pain
GO:0032026 response to magnesium ion
GO:0043523 regulation of neuron apoptotic process
GO:0045892 negative regulation of DNA-templated transcription
GO:0048265 response to pain
GO:0048266 behavioral response to pain
GO:0071805 potassium ion transmembrane transport
GO:0072659 protein localization to plasma membrane
GO:1901379 regulation of potassium ion transmembrane transport
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0032993 protein-DNA complex
GO:0034702 monoatomic ion channel complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2jul, PDBe:2jul, PDBj:2jul
PDBsum2jul
PubMed18201103
UniProtQ9QXT8|CSEN_MOUSE Calsenilin (Gene Name=Kcnip3)

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