Structure of PDB 2jr7 Chain A Binding Site BS01

Receptor Information
>2jr7 Chain A (length=84) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MAVFHDEVEIEDFQYDEDSETYFYPCPCGDNFSITKEDLENGEDVATCPS
CSLIIKVIYDKDQFVSGETVPAPSANKELVKLEH
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2jr7 Chain A Residue 85 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB2jr7 Solution structure of human DESR1, a CSL zinc-binding protein
ResolutionN/A
Binding residue
(original residue number in PDB)		C26 C48 C51
Binding residue
(residue number reindexed from 1)		C26 C48 C51
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008198 ferrous iron binding
GO:0034986 iron chaperone activity
GO:0046872 metal ion binding
Biological Process
GO:0002926 tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation
GO:0017183 protein histidyl modification to diphthamide
GO:0050709 negative regulation of protein secretion
GO:0051099 positive regulation of binding
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2jr7, PDBe:2jr7, PDBj:2jr7
PDBsum2jr7
PubMed18214955
UniProtQ96FX2|DPH3_HUMAN Diphthamide biosynthesis protein 3 (Gene Name=DPH3)

[Back to BioLiP]