Structure of PDB 2jly Chain A Binding Site BS01

Receptor Information
>2jly Chain A (length=451) Species: 408688 (Dengue virus 4 Thailand/0348/1991) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSAMGEPDYEVDEDIFRKKRLTIMDLHPGAGKTKRILPSIVREALLRRLR
TLILAPTRVVAAEMEEALRGLPIRYQTPAVKSDHTGREIVDLMCHATFTT
RLLSSTRVPNYNLIVMDEAHFTDPCSVAARGYISTRVEMGEAAAIFMTAT
PPGSTDPFPQSNSPIEDIEREIPERSWNTGFDWITDYQGKTVWFVPSIKA
GNDIANCLRKSGKRVIQLSRKTFDTEYPKTKLTDWDFVVTTDISEMGANF
RAGRVIDPRRCLKPVILTDGPERVILAGPIPVTPASAAQRRGRIGRNPAQ
EDDQYVFSGDPLKNDEDHAHWTEAKMLLDNIYTPEGIIPTLFGPEREKTQ
AIDGEFRLRGEQRKTFVELMRRGDLPVWLSYKVASAGISYKDREWCFTGE
RNNQILEENMEVEIWTREGEKKKLRPKWLDARVYADPMALKDFKEFASGR
K
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2jly Insights Into RNA Unwinding and ATP Hydrolysis by the Flavivirus Ns3 Protein.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		T224 R225 R241 Q243 T244 P245 C261 A263 T264 R268 S271 D290 P363 S364 I365 S386 R387 T408 I410 P431 R599
Binding residue
(residue number reindexed from 1)		T57 R58 R74 Q76 T77 P78 C94 A96 T97 R101 S104 D123 P196 S197 I198 S219 R220 T241 I243 P264 R432
Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0004386 helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:2jly, PDBe:2jly, PDBj:2jly
PDBsum2jly
PubMed19008861
UniProtQ2YHF0|POLG_DEN4T Genome polyprotein

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