Structure of PDB 2j9a Chain A Binding Site BS01

Receptor Information

>2j9a Chain A (length=485) Species: 9913 (Bos taurus)

TKGLVLGIYSKEKEEDEPQFTSAGENFNKLVSGKLREILNISGPPLKAGK
TRTFYGLHEDFPSVVVVGLGKKTAGIDEQENWHEGKENIRAAVAAGCRQI
QDLEIPSVEVDPCGDAQAAAEGAVLGLYEYDDLKQKRKVVVSAKLHGSED
QEAWQRGVLFASGQNLARRLMETPANEMTPTKFAEIVEENLKSASIKTDV
FIRPKSWIEEQEMGSFLSVAKGSEEPPVFLEIHYKGSPNASEPPLVFVGK
GITFDSGGISIKAAANMDLMRADMGGAATICSAIVSAAKLDLPINIVGLA
PLCENMPSGKANKPGDVVRARNGKTIQVDNTDAEGRLILADALCYAHTFN
PKVIINAATLTGAMDIALGSGATGVFTNSSWLWNKLFEASIETGDRVWRM
PLFEHYTRQVIDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHLDI
AGVMTNKDEVPYLRKGMAGRPTRTLIEFLFRFSQE

Ligand information

>2j9a Chain D (length=4) Species: 1127 (Microcystis sp.)

ALYY

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2j9a Binding Structure of the Leucine Aminopeptidase Inhibitor Microginin Fr1.
• Resolution: 1.73 Å
• Binding residue (original residue number in PDB): D332 G362 I421 G422 Y424 R425
• Binding residue (residue number reindexed from 1): D332 G362 I421 G422 Y424 R425

Enzymatic activity

• Catalytic site (original residue number in PDB): K262 R336
• Catalytic site (residue number reindexed from 1): K262 R336
• Enzyme Commision number: 3.4.11.1: leucyl aminopeptidase.
  3.4.11.5: prolyl aminopeptidase.
  3.4.13.23: cysteinylglycine-S-conjugate dipeptidase.

Gene Ontology

Molecular Function

• GO:0004177 aminopeptidase activity
• GO:0004180 carboxypeptidase activity
• GO:0008233 peptidase activity
• GO:0016805 dipeptidase activity
• GO:0030145 manganese ion binding
• GO:0046872 metal ion binding
• GO:0070006 metalloaminopeptidase activity
• GO:0097718 disordered domain specific binding

Biological Process

• GO:0006508 proteolysis
• GO:0019538 protein metabolic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005739 mitochondrion

External links

• PDB: RCSB:2j9a, PDBe:2j9a, PDBj:2j9a
• PDBsum: 2j9a
• PubMed: 17157838
• UniProt: P00727|AMPL_BOVIN Cytosol aminopeptidase (Gene Name=LAP3)